Genome-wide Integration Study of Circulating-miRNAs and Peripheral Whole Blood-mRNAs of Male Acute Ischemic Stroke Patients.

•Bioinformatic integration of the circulating miRNA and peripheral whole-blood mRNA networks expressed during male AIS.•Twenty-four mRNAs in peripheral whole blood overlapped with the regulation of seven circulating miRNAs.•Common up-regulation of circulating miRNAs and targeted mRNAs were observed under AIS stress.•The overlapped mRNAs were associated with platelet degranulation and immune response.•The overlapped mRNAs were associated with phagosome biology and Staphylococcus aureus infection.