BET bromodomain inhibitors show anti-papillomavirus activity in vitro and block CRPV wart growth in vivo.

Mary A Morse,Karla K Balogh,Sarah A Brendle,Colin A Campbell, Mao X Chen,Rebecca C Furze, Isobel L Harada, Ian D Holyer,Umesh Kumar,Kevin Lee,Rab K Prinjha,Martin Rüdiger,Jonathan T Seal,Simon Taylor,Jason Witherington,Neil D Christensen

Antiviral Research（2018）

引用 14|浏览48

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摘要

The DNA papillomaviruses infect squamous epithelium and can cause persistent, benign and sometimes malignant hyperproliferative lesions. Effective antiviral drugs to treat human papillomavirus (HPV) infection are lacking and here we investigate the anti-papillomavirus activity of novel epigenetic targeting drugs, BET bromodomain inhibitors.

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关键词

Human papillomavirus,Epigenetics,Bromodomain extra-terminal domain protein,BRD4,BET inhibitor

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