CD10 inhibits cell motility but expression is associated with advanced stage disease in colorectal cancer

Teresa P. Raposo, Mireia Sueca Comes, Adeyemi Idowu,Bora Agit,James Hassall,Wakkas Fadhil,Robert Nica,Rupert Ecker,Takashi Yao,Mohammad Ilyas

Experimental and Molecular Pathology（2018）

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摘要

•Upon CD10 knockdown in SW480 but not in SW620, migration and invasion increase•CD10 Knockdown in SW480 caused a cadherin switch typical of EMT.•CD10 expression in primary CRC was associated with advanced Duke's stage (C1/C2).•CD10 function may depend on the tumour microenvironment and stage of development.

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关键词

CD10,NEP,CALLA,Colorectal cancer,Epithelial-mesenchymal transition,Metastasis

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