[A weak D type 59 case identified in the Chinese Han population].

OBJECTIVE:To study a case with weak D59 phenotype identified among ethnic Han Chinese population. METHODS:Routine serological tests were used to analyze the reaction patterns, and the RhD epitopes were verified with 12 monoclonal antibodies. Sequence-specific primer PCR was applied for typing the weak RhD and RhD zygosity in the proband and his family members. RESULTS:A c.1148T>C variant was identified in the proband, for which serological test indicated a weak D phenotype. RHD zygosity testing confirmed that the proband had a RHD+ /RHD- genotype. CONCLUSION:A weak D59 phenotype was firstly identified in a Chinese individual.