Loss of dorsomedial hypothalamic GLP-1 signaling reduces BAT thermogenesis and increases adiposity.

Shin J Lee,Graciela Sanchez-Watts,Jean-Philippe Krieger,Angelica Pignalosa, Puck N Norell,Alyssa Cortella, Klaus G Pettersen, Dubravka Vrdoljak,Matthew R Hayes,Scott E Kanoski,Wolfgang Langhans,Alan G Watts

Molecular Metabolism（2018）

引用 64|浏览13

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摘要

•DMH GLP-1R stimulation acutely increases BAT thermogenesis.•DMH GLP-1R mRNA knockdown decreases EE and BAT thermogenesis.•DMH GLP-1R mRNA knockdown impairs lipid and glucose metabolism.•Reduced DMH GLP-1R signaling blunts the anorexigenic responses to Ex-4.•DMH GLP-1R signaling indirectly regulates NPY gene expression.

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关键词

Neuropeptide,Hypothalamus,Sympathetic nerve,Adipose tissue,Obesity

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