NAMPT inhibitor protects ischemic neuronal injury in rat brain via anti-neuroinflammation

Chen-Xiang Chen, Jing Huang,Ga-Qi Tu, Jia-Tong Lu,Xian Xie, Bing Zhao,Ming Wu,Qiao-Juan Shi,San-Hua Fang,Er-Qing Wei,Wei-Ping Zhang,Yun-Bi Lu

Neuroscience（2017）

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摘要

•NAMPT in microglia/macrophages participates in neuroinflammation after cerebral ischemia.•NAMPT inhibitor inhibited neuroinflammation after cerebral ischemia.•NAMPT inhibitors protect neurons from ischemia via anti-neuroinflammation.

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关键词

ECA,EI,ELISA,GFAP,ICA,MCA,MCAO/R,MTT,NAD,NAMPT,NeuN,NMN,OGD/R,PBS

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