FGF18 protects against 6-hydroxydopamine-induced nigrostriatal damage in a rat model of Parkinson's disease.

Xingzhi Guo,Tingting Liu,Diandian Zhao,Xiaofeng Wang,Dongmei Liu,Yang He,Chang Shan,Yingying Kong,Weiwei Hu,Bei Tao,Lihao Sun,Hongyan Zhao,Shengtian Li,Jianmin Liu

Neuroscience（2017）

引用 10|浏览18

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摘要

•FGF18 significantly ameliorates movement impairment in 6-OHDA-induced rat model.•FGF18 treatment prevents 6-OHDA-induced dopaminergic neuronal loss in the substantia nigra.•FGF18 protects PC12 cell from 6-OHDA-induced neurotoxicity via AKT/GSK3β pathway.

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关键词

6-OHDA,7-AAD,DMEM,EBST,FGF18,FGFRs,GDNF,HSPGs,MAPK,OFT,PBS,PD,PFA,PI3K,SN,ST,TH

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