Low dystrophin levels are insufficient to normalize the neuromuscular synaptic abnormalities of mdx mice.

Elizabeth M van der Pijl,Maaike van Putten,Erik H Niks,Jan J G M Verschuuren,Annemieke Aartsma-Rus,Jaap J Plomp

Neuromuscular Disorders（2018）

引用 16|浏览15

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摘要

•Dystrophin levels lower than 19% of normal do not restore aberrations of mdx NMJs•Mdx+/- NMJs have normal functional and morphological synaptic features•Dystrophin threshold for normal NMJ function and morphology lies between 19% and 50%

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关键词

Acetylcholine receptor,Duchenne muscular dystrophy,Dystrophin,mdx mice,Neuromuscular junction,Synaptic transmission

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