Activation of choline kinase drives aberrant choline metabolism in esophageal squamous cell carcinomas.
Journal of Pharmaceutical and Biomedical Analysis(2018)
摘要
•A global metabolomic approach for biomarkers and mechanisms in ESCC is proposed.•ESCC patient have significantly different metabolites profiles than health volunteer.•Dysregulated lipid metabolism was an important characteristic in ESCC patients.•Dysregulated choline and phosphatidylcholines were related to Chok overexpression.•Phosphatidylcholines and Chok may serve as novel biomarkers for ESCC.
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关键词
ESCC,2D LC–MS,FFA,PC,Chok,ESI,PCA,PLS-DA,HCA,IHC,TMAs,DAB,QC,LPC,PC-MUFA,PC-PUFA,PC-SFA,PE,cPLA2
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