Motor and non-motor features of Parkinson's disease in LRRK2 G2019S carriers versus matched controls.

Steven A Gunzler,David E Riley,Shu G Chen,Curtis M Tatsuoka,William M Johnson,John J Mieyal,Ellen M Walter,Christina M Whitney,I Jung Feng, Harry Owusu-Dapaah,Shivam O Mittal,Amy L Wilson-Delfosse

Journal of the Neurological Sciences（2018）

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摘要

•LRRK2 G2019S is a common genetic mutation in familial Parkinson's disease (PD).•We sought to determine phenotype and prevalence of LRRK2 G2019S carriers with PD.•We determined PD phenotype and LRRK2 G2019S carrier status in 231 subjects.•13% of Ashkenazi Jewish (AJ) and 1% of non-AJ subjects were LRRK2 G2019S carriers.•PD phenotype was similar between LRRK2 G2019S carriers and matched PD controls.

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关键词

Leucine-rich repeat kinase,Autosomal dominant,Parkinson's disease,Motor features,Non-motor features,Cognition

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