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Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor.

Christopher J. Helal,Eric P. Arnold,Tracey L. Boyden,Cheng Chang,Thomas A. Chappie,Kimberly F. Fennell,Michael D. Forman,Mihaly Hajos,John F. Harms,William E. Hoffman,John M. Humphrey,Zhijun Kang,Robin J. Kleiman,Bethany L. Kormos,Che-Wah Lee,Jiemin Lu,Noha Maklad,Laura McDowell,Scot Mente,Rebecca E. O'Connor,Jayvardhan Pandit,Mary Piotrowski,Anne W. Schmidt,Christopher J. Schmidt,Hirokazu Ueno,Patrick R. Verhoest,Edward X. Yang

Journal of Medicinal Chemistry（2017）

Cited 26|Views36
Key words
Compartmentalized Signaling
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