Ablative Hypofractionated Radiation Therapy Enhances Non-Small Cell Lung Cancer Cell Killing via Preferential Stimulation of Necroptosis In Vitro and In Vivo.

Huan-Huan Wang,Zhi-Qiang Wu,Dong Qian,Nicholas G Zaorsky,Ming-Han Qiu,Jing-Jing Cheng,Chao Jiang,Juan Wang,Xian-Liang Zeng,Chun-Lei Liu,Li-Jun Tian,Guo-Guang Ying,Mao-Bin Meng,Xi-Shan Hao,Zhi-Yong Yuan

International Journal of Radiation Oncology*Biology*Physics（2018）

引用 36|浏览59

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摘要

Ablative HFRT at ≥10 Gy per fraction enhances killing of NSCLC with high RIP3 expression via preferential stimulation of necroptosis. RIP3 may serve as a useful biomarker to predict favorable response to stereotactic body radiation therapy.

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