Oxidative stress enhances tumorigenicity and stem-like features via the activation of the Wnt/β-catenin/MYC/Sox2 axis in ALK-positive anaplastic large-cell lymphoma.

Chengsheng Wu,Nidhi Gupta,Yung-Hsing Huang,Hai-Feng Zhang,Abdulraheem Alshareef,Alexandra Chow,Raymond Lai

BMC cancer（2018）

引用 17|浏览4

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摘要

We have demonstrated that cancer cell plasticity exists in ALK+ALCL, a type of hematopoietic cancer. In this cancer type, the Wnt/β-catenin/MYC/Sox2 axis is an important regulator of cancer cell plasticity.

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关键词

Anaplastic large-cell lymphoma,Oxidative stress,Cancer cell plasticity,Intra-tumoral heterogeneity

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