The L83L ORF of African swine fever virus strain Georgia encodes for a non-essential gene that interacts with the host protein IL-1β.

Manuel V Borca,Vivian O'Donnell,Lauren G Holinka,Elizabeth Ramírez-Medina,Benjamin A Clark,Elizabeth A Vuono,Keith Berggren,Marialexia Alfano,Lucas B Carey,Juergen A Richt,Guillermo R Risatti,Douglas P Gladue

Virus Research（2018）

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摘要

•L83L is an early expressed protein in ASFV.•L83L is a binding partner for host protein Il-1β.•Deletion of L83L in ASFV does not decrease virus virulence in swine.

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