Role of the Cortico-Subthalamic Hyperdirect Pathway in Deep Brain Stimulation for the Treatment of Parkinson Disease: A Diffusion Tensor Imaging Study

•STN-DBS can influence the pathological activity of the cortex through antidromic activation of the HDP.•Stimulation of the HDP was correlated with the improvement of motor symptoms in patients with PD.•An improvement of the direct visualization method based on fiber tractography achieves more precise target location and helps guide individualized treatment.