Immune Cell Production of Interleukin 17 Induces Stem Cell Features of Pancreatic Intraepithelial Neoplasia Cells.

Yu Zhang, Michelle Zoltan,Erick Riquelme,Hanwen Xu,Ismet Sahin,Susana Castro-Pando, Maria Fernanda Montiel,Kyle Chang,Zhengyu Jiang,Jianhua Ling,Sonal Gupta,William Horne,Melissa Pruski,Huamin Wang,Shao-Cong Sun,Guillermina Lozano,Paul Chiao,Anirban Maitra, Steven D Leach,Jay K Kolls,Eduardo Vilar,Timothy C Wang,Jennifer M Bailey,Florencia McAllister

Gastroenterology（2018）

引用 103|浏览60

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摘要

In studies of mouse and human pancreatic tumors and precursors, we found immune cell-derived IL17 to regulate development of tuft cells and stem cell features of pancreatic cancer cells via increased expression of DCLK1, POU2F3, ALDH1A1, and IL17RC. Strategies to disrupt this pathway might be developed to prevent pancreatic tumor growth and progression.

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关键词

Immune Response,Kras,PDAC,Tumorigenesis

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