Error thresholds for RNA replication in the presence of both point mutations and premature termination errors.

Journal of Theoretical Biology(2017)

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摘要
•Premature termination of RNA replication generates short non-functional strands that replicate faster than the polymerase.•The polymerase can survive in the presence of fast-replicating parasite strands due to spatial pattern formation.•The error threshold for termination errors is much less than for point mutations if replication rate varies inversely with strand length.•If binding of a polymerase to a template is slow compared to polymerization, the two error thresholds become equal.
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关键词
RNA world,Polymerase,Ribozyme,Error threshold,Termination error,Point mutation,Parasite
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