A single vaccination with non-replicating MVA at birth induces both immediate and long-term protective immune responses.

Cédric Cheminay,Jana Körner,Constanze Bernig,Michael Brückel,Markus Feigl, Martin Schletz,Mark Suter,Paul Chaplin,Ariane Volkmann

Vaccine（2018）

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摘要

•Effective B-cell and T-cell induction with a single MVA vaccination at birth.•Complete protection of newborn mice against lethal poxvirus infection.•Immediate, but also long-lasting protection after a single neonatal vaccination.•Mechanism of protection elucidated.

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关键词

MVA,Neonatal vaccination,Smallpox vaccine,Mouse,Ectromelia virus

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