New dianthramide and cinnamic ester glucosides from the roots of Aconitum carmichaelii.

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH(2019)

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摘要
Four new compounds N-salicyl-3-hydroxyanthranilic acid methyl ester (1), N-(2 '-dehydroxysalicyl)-3-hydroxyanthranilic acid methyl ester (2), methyl-4-beta-D-allopyranosyl-ferulate (3), and methyl-4-beta-D-gulopyranosyl-cinnamate (4), along with six known compounds (5-10), were isolated from the roots of Aconitum carmichelii Debx. Their structures were elucidated on the basis of spectral data analysis, including 1D, 2D-NMR, and HR-ESI-MS. Compounds 1 and 2 showed the inhibition of nitric oxide (NO) production with IC50 values of 9.13 and 19.94 mu M, respectively. [GRAPHICS] .
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Aconitum carmichaelii,Ranunculaceae,NO production inhibition,dianthramide,cinnamic ester glucoside
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