Exenatide has a Pronounced Effect on Energy Intake but not Energy Expenditure in Non-Diabetic Subjects with Obesity: A Randomized, Double-blind, Placebo-Controlled Trial.

•Exenatide has an early and pronounced absolute change in daily energy intake.•Decrease in food intake relative to WMEN was less pronounced than absolute reduction.•Exenatide has no effect on energy expenditure.•Exenatide has a modest effect on weight loss at 5 weeks.•Effect on energy intake appeared to wane over long term follow-up.