Determination of edoxaban equivalent concentrations in human plasma by an automated anti-factor Xa chromogenic assay.

•Anti-FXa assays for measuring direct oral anticoagulants may be clinically useful.•Performance of anti-FXa assays calibrated for edoxaban have not been demonstrated.•An anti-FXa assay demonstrated good accuracy in estimating edoxaban concentrations.•Edoxaban concentration in Na citrate vs heparin collection tubes were compared.