Up-regulation of miR-325-3p suppresses pineal aralkylamine N-acetyltransferase (Aanat) after neonatal hypoxia-ischemia brain injury in rats.

Yuanyuan Yang,Bin Sun,Jian Huang,Lixiao Xu,Jian Pan,Chen Fang,Mei Li,Gen Li,Yanfang Tao,Xiaofeng Yang,Ying Wu,Po Miao,Ying Wang,Hong Li,Jing Ren,Meiqin Zhan, Yiping Fang,Xing Feng,Xin Ding

Brain Research（2017）

引用 41|浏览29

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摘要

•miR-325-3p is up-regulated post hypoxic-ischemic brain damage.•miR-325-3p binds the 3′-UTR of Aanat mRNA.•miR-325-3p blocks Aanat activation in pinealocytes.•miR-325-3p inhibitor rescues the Aanat impairment in pinealocytes with OGD.

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关键词

miR-325-3p,Aanat,HIBD,Pineal gland,Running wheel,Circadian rhythm disorders

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