Potential role for Ext1-dependent heparan sulfate in regulating P311 gene expression in A549 carcinoma cells.

Kirankumar Katta,Lawrence F Sembajwe,Marion Kusche-Gullberg

Biochimica et Biophysica Acta (BBA) - General Subjects（2018）

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摘要

•Ext1 has a central role in regulation heparan sulfate dependent cellular signaling.•Reduced Ext1 levels decreases the expression and secretion of active TGF-β.•Fibroblast Ext1 levels influence P311 expression in adjacent A549 cells via TGF-β1.•A possible novel mechanism of Ext1 dependent stromal heparan sulfate-tumor interaction

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关键词

Heparan sulfate,EXT1,Fibroblasts,A549 adenocarcinoma cells,P311,TGF-beta

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