Pharmacological, but not genetic, alteration of neural Epo modifies the CO/H central chemosensitivity in postnatal mice.

Sofien Laouafa,Anne-Sophie Perrin-Terrin,Florine Jeton,Elizabeth Elliot-Portal,Rose Tam,Laurence Bodineau,Nicolas Voituron,Jorge Soliz

Respiratory Physiology & Neurobiology（2017）

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摘要

•The central chemosensitivity is not altered in brainstem-spinal cord preparations of transgenic mice overexpressing erythropoietin.•The central chemosensitivity is not altered in brainstem-spinal cord preparations of transgenic mice deficient for erythropoietin.•The pharmacological alteration of neural Epo alters the central chemosensitivity in brainstem-spinal cord preparations of mice.

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关键词

Newborn mice,Erythropoietin,Soluble erythropoietin receptor,Respiration,Central chemosensitivity,Hypercapnia,ERK/Akt

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