Burden-driven feedback control of gene expression

Francesca Ceroni,Alice Boo,Simone Furini,Thomas E Gorochowski,Olivier Borkowski,Yaseen N Ladak,Ali R Awan,Charlie Gilbert,Guy-Bart Stan,Tom Ellis

NATURE METHODS（2018）

引用 233|浏览36

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摘要

In this CRISPR-based feedback control system, sgRNA expression is triggered by the burden of protein overexpression, and the sgRNA directs repression of the exogenous gene promoter to reduce burdensome expression and restore growth of the cell.

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关键词

gene expression,feedback control,burden-driven

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