Regional-specific effects of cerebral ischemia/reperfusion and dehydroepiandrosterone on synaptic NMDAR/PSD-95 complex in male Wistar rats.

Marina Zaric,Dunja Drakulic,Ivana Gusevac Stojanovic,Natasa Mitrovic,Ivana Grkovic,Jelena Martinovic

Brain Research（2018）

引用 9|浏览14

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摘要

•I/R-induced HIP vGluT1, NR1, NR2B subunits increase and PSD-95 decrease.•CA1 neuronal damage accompanies detected protein level changes.•NR1 subunit reduction in PFC is associated with layer III neuronal damage.•DHEA in physiological condition doesn’t affect protein level or neuronal morphology.•DHEA restores I/R-induced changes of HIP PSD-95 and PFC NR1 protein level.

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关键词

Cerebral ischemia/reperfusion,Dehydroepiandrosterone,Glutamatergic neurotransmission,Synaptosomes,Hippocampus,Prefrontal cortex

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