A phase III, open-label, randomised multicentre study to evaluate the immunogenicity and safety of a booster dose of two different reduced antigen diphtheria-tetanus-acellular pertussis-polio vaccines, when co-administered with measles-mumps-rubella vaccine in 3 and 4-year-old healthy children in the UK.
Vaccine(2018)
摘要
•We assessed immunogenicity and safety of dTpa-IPV booster vaccine in 3–4 years olds.•The immunogenicity of dTpa-IPV (Boostrix-IPV) was non-inferior to Repevax.•Both vaccines were co-administered with mumps-measles-rubella vaccine.•Both vaccines had clinically acceptable safety and reactogenicity profiles.
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AE,ap,ATP,CI,d,D,dTap-IPV,ELISA,EMA,El.U/ml,FHA,GMC,GMT,IPV,IU/ml,m,MMR,PRN,PT,SAE,T,y
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