Autoantibodies targeting TLR and SMAD pathways define new subgroups in systemic lupus erythematosus.

Myles J Lewis,Michael B McAndrew,Colin Wheeler,Nicholas Workman,Pooja Agashe,Jens Koopmann,Ezam Uddin,David L Morris,Lu Zou,Richard Stark,John Anson,Andrew P Cope,Timothy J Vyse

Journal of Autoimmunity（2018）

引用 44|浏览16

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摘要

•Protein microarray reveals molecular identity of 68 novel SLE autoantigens.•SLE autoantibodies cluster into four biologically functional groups.•SLE autoantigen clusters link to TGF-β/Wnt signalling and TLR signalling/apoptosis regulation.•Novel autoantibodies show selectivity for different SLE manifestations (arthritis, renal, thrombocytopenia).•26-autoantibody panel improves diagnostic accuracy compared to conventional serology.

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关键词

Systemic lupus erythematosus,Autoantibodies,Autoimmunity,Personalised medicine,Diagnostic assay,Protein microarray

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