SOX2 expression diminishes with ageing in several tissues in mice and humans.

Estefania Carrasco-Garcia,Leire Moreno-Cugnon,Idoia Garcia,Consuelo Borras,Miren Revuelta,Ander Izeta,Guillermo Lopez-Lluch,Marian M de Pancorbo,Itziar Vergara,Jose Vina,Ander Matheu

Mechanisms of Ageing and Development（2019）

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摘要

•SOX2 levels decrease in human and mouse brain biopsies with age.•High levels of SOX2 correlates with resveratrol long treatment in brain samples.•SOX2 expression decreases in several tissues of 2 years-old mice.•SOX2 expression decreases in PBMCs of over 75 years-old individuals.•There is an inverse correlation between SOX2 and p16Ink4a expression.

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关键词

SOX2,Ageing,Biomarker

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