Increased building block access through collaboration.

Christopher J Helal,Alessandra Bartolozzi, Steven D Goble, Neelakanda S Mani,Angel Guzman-Perez, Ajay K Ohri,Zhi-Cai Shi,Chakrapani Subramanyam

Drug Discovery Today（2018）

引用 9|浏览29

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摘要

•Fluorine can impact potency, selectivity and ADME of medicinal chemistry analogs.•Fluorinated building blocks (FBB) greatly enable fluorinated analog preparation.•Some vendor-listed FBB are expensive because many have not been synthesized.•A vendor–pharma Buying Group was created to share costs and reduce FBB prices.•The details of the Buying Group formation, FBB usage and conclusions are presented.

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关键词

Building block,buying group,fluorine

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