Tocoyena sellowiana extract decreases bone loss in an experimental model of periodontitis in rats: Putative role for cyclooxygenase-2 and IL-1β inhibition

Debora da Silva Freitas Ribeiro,Jordânia Marques de Oliveira Freire,Alrieta Henrique Teixeira,Danielle Rocha do Val,Alice Ramos de Freitas,Francisco Isaac Fernandes Gomes,Antonio Alfredo Rodrigues e Silva,Paulo Nogueira Bandeira,Helcio Silva dos Santos, William Paulo dos Santos,Fábio Nascimento Ávila,Karuza Maria Alves Pereira,Paula Goes,Vicente de Paulo Teixeira Pinto,Gerardo Cristino-Filho,Maria Rose Jane Ribeiro Albuquerque,Hellíada Vasconcelos Chaves,Mirna Marques Bezerra

BIOMEDICINE & PHARMACOTHERAPY（2018）

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摘要

•Periodontitis is an inflammatory disease and causes periodontal tissue breakdown.•Tocoyena sellowiana is largely used in Brazil as a medicinal plant.•Tocoyena sellowiana decreased bone loss, MPO, IL-1β levels, and COX-2 immunostaining.•Tocoyena sellowiana did not alter organs and body weight.

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关键词

Tocoyena sellowiana,Periodontitis,Sub-chronic toxicity

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