Interleukin 35: Inhibitory regulator in monocyte-derived dendritic cell maturation and activation.

Xi Chen,Shengnan Hao,Zhonghua Zhao,Jia Liu,Qianqian Shao,Fang Wang,Dong Sun,Ying He,Wenjuan Gao,Haiting Mao

Cytokine（2018）

引用 24|浏览23

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摘要

•IL-35 suppresses MoDC maturation.•IL-35-treated MoDCs inhibit proliferation of CD4+/CD8+ T cells.•IL-35-treated MoDCs suppress polarization of Th1 and CD8+T cells allogeneic response.•IL-35 inhibits MoDC maturation through aberrant activation of STAT1/STAT3.

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关键词

Interleukin 35,Monocyte-derived dendritic cell,CD4+T cell,CD8+T cell,Immunosuppression

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