The role of hyaluronan as a drug carrier to enhance the bioavailability of extended release ophthalmic formulations. Hyaluronan-timolol ionic complexes as a model case.

European Journal of Pharmaceutical Sciences(2017)

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摘要
The aim of this work was to obtain information concerning the properties of ophthalmic formulations based on hyaluronic-drug ionic complexes, to identify the factors that determine the onset, intensity and duration of the pharmacotherapeutic effect.
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关键词
Hyaluronan,Ocular drug delivery,Drug–polyelectrolyte complex,Pharmacokinetics,Pharmacodynamics,Pre-corneal residence time,Glaucoma treatment
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