Immunomodulatory and Antibacterial Properties of the Chumash Medicinal Plant Trichostema lanatum.
Medicines (Basel, Switzerland)(2018)
摘要
The woody shrub Benth. (Lamiaceae) is native to Southern California and was reportedly used by the Chumash people as a disinfectant and for the treatment of rheumatism. Based on its traditional uses, this study investigated the antibacterial and immunomodulatory properties of extracts from A methanolic extract of the leaves and stems of was tested for immunomodulatory activity by measuring the proliferation of murine macrophage cell cultures and the production of the pro-inflammatory cytokine TNF-α by the cells after treatment with . Antibacterial activity of the extract against a panel of six Gram-positive bacteria and two Gram-negative bacteria was evaluated using a disc-diffusion assay. The extract inhibited the growth of Gram-positive bacteria, but not Gram-negative bacteria. Treatment of activated macrophage cell cultures with extract resulted in decreased proliferation of the activated macrophages and a decrease in the production of TNF-α. These results provide the first pharmacological support for the traditional use of by the Chumash people of Southern California as a disinfectant and treatment for rheumatism.
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关键词
TNF-α,Trichostema lanatum,antibacterial,immunomodulatory,macrophage,traditional medicines of North America
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