Experimental models for evaluating non-genomic estrogen signaling.

Steroids(2018)

引用 32|浏览8
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摘要
•E2 induces non-genomic signals through membrane estrogen receptors.•Multiple models face challenges excluding strong nucleophilic ERα.•H2NES ERα exists only in cytoplasm and maintains E2-mediated rapid actions.•H2NES ERα does not activate E2-responsive endogenous genes.•H2NES ERα is a new experimental model for ERα mediated non-genomic actions.
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关键词
Estrogen receptor alpha,Non-genomic signaling,Rapid action
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