MiR-16 regulates the pro-tumorigenic potential of lung fibroblasts through the inhibition of HGF production in an FGFR-1- and MEK1-dependent manner.

Francesca Andriani,Maria Teresa Majorini,Miguel Mano,Elena Landoni,Rosalba Miceli,Federica Facchinetti,Mavis Mensah,Enrico Fontanella,Matteo Dugo,Mauro Giacca,Ugo Pastorino,Gabriella Sozzi,Domenico Delia,Luca Roz,Daniele Lecis

Journal of hematology & oncology（2018）

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摘要

Overall, these results uncover a central role for miR-16 in regulating HGF production by lung fibroblasts, thus affecting their pro-tumorigenic potential. Correlation between smoking exposure and miR-16 levels could provide novel clues regarding the formation of a tumor-proficient milieu during the early phases of lung cancer development.

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关键词

Cancer cell migration,FGFR-1 signaling,Lung cancer,Tumor microenvironment,miR-16

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