In vitro characterization of arylhydrazones of active methylene derivatives.

Suresh Palanivel,Anastasia Zhurina,Phuong Doan,Jerome G Chandraseelan,Vinoth Kumar Megraj Khandelwal,Fedor I Zubkov,Kamran T Mahmudov,Armando J L Pombeiro,Olli Yli-Harja,Meenakshisundaram Kandhavelu

Saudi Pharmaceutical Journal（2018）

引用 4|浏览18

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摘要

•AHAMCs derivatives induce cytotoxicity in immortal cells at “mM” range.•5-(2-(2-hydroxyphenyl) hydrazono)pyrimidine-2,4,6(1H,3H,5H)-trione cause cell death by apoptosis and nexrosis.•5-(2-(2-hydroxyphenyl) hydrazono)pyrimidine-2,4,6(1H,3H,5H)-trione calcium-mediated apoptosis.•5-(2-(2-hydroxyphenyl) hydrazono)pyrimidine-2,4,6(1H,3H,5H)-trione induce selective cytotoxicity in U87G and 1321 N1 at “µM” range.

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关键词

Arylhydrazones of active methylene compounds,Cytotoxic effect,Apoptosis,Immortal cells,Glioma,Single cell analysis,Chemotherapy

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