Antidepressant effects of magnolol in a mouse model of depression induced by chronic corticosterone injection.

Yongtao Bai,Lihua Song,Guoliang Dai,Meijuan Xu,Lijing Zhu,Weidong Zhang,Wen Jing,Wenzheng Ju

Steroids（2018）

引用 54|浏览24

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摘要

•Repeated chronic CORT treatment resulted in depressive-like behaviors.•We firstly found magnolol alleviated CORT-induced depressive behaviors.•Magnolol modulated HPA axis by reducing CORT levels.•Magnolol reversed the levels of BDNF, 5-TH and NE in CORT-treated mice.

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关键词

Magnolol,Corticosterone,Antidepressant,Brain-derived neurotrophic factor

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