A Comparison of the Myeloablative Conditioning Regimen Fludarabine/Busulfan with Cyclophosphamide/Total Body Irradiation, for Allogeneic Stem-Cell Transplantation in the Modern Era: a Cohort Analysis.

Mahasweta Gooptu,Haesook T Kim,Vincent T Ho,Edwin P Alyea,John Koreth,Philippe Armand,Jerome Ritz,Sarah Nikiforow,Brett E Glotzbecker,Prashant Nageshwar,Robert J Soiffer,Joseph H Antin,Corey S Cutler

Biology of Blood and Marrow Transplantation（2018）

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摘要

•FluBu and CyTBI are common myeloablative conditioning regimens for HSCT.•Overall survival is superior with FluBu for hematologic malignancies.•Nonrelapse mortality and grade II to IV aGVHD are better with FluBu, while relapse is similar.•Outcomes with FluBu are better at age <55 years as well and in myeloid malignancies.

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关键词

Myeloablative,Allogeneic transplant,Reduced toxicity,Fludarabine,Graft-versus-host disease

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