mTORC1 pathway disruption abrogates the effects of the ciliary neurotrophic factor on energy balance and hypothalamic neuroinflammation.

Caroline André,Caterina Catania, Julie Remus-Borel,Elodie Ladeveze,Thierry Leste-Lasserre,Wilfrid Mazier,Elke Binder,Delphine Gonzales,Samantha Clark,Omar Guzman-Quevedo,Djoher Nora Abrous,Sophie Layé,Daniela Cota

Brain, Behavior, and Immunity（2018）

引用 14|浏览45

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摘要

•CNTFAx15 requires S6K1 to decrease body weight in HFD-fed mice.•CNTFAx15 induces microglia activity and astrogliosis in the ARC of the hypothalamus.•S6K1 determines hypothalamic inflammatory responses to CNTFAx15.

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关键词

Obesity,Inflammation,CNTF,S6K1,mTOR,Microglia,Glia cells,Hypothalamus

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