Abnormal emotional and neural responses to romantic rejection and acceptance in depressed women.

•Women with and without depression received romantic social feedback during fMRI.•The depressed group was emotionally hyperresponsive to rejection and acceptance.•Rejection elicited strong activity in the right anterior insula only in depressed women.•Happiness after acceptance was mediated by striatal activity only in healthy women.•Abnormal responses to social cues may impact the prognosis of depression.