Multi-centre normative brain mapping of intracranial EEG lifespan patterns in the human brain
arxiv(2024)
摘要
Background: Understanding healthy human brain function is crucial to identify
and map pathological tissue within it. Whilst previous studies have mapped
intracranial EEG (icEEG) from non-epileptogenic brain regions, these maps do
not consider the effects of age and sex. Further, most existing work on icEEG
has often suffered from a small sample size due to this modality's invasive
nature. Here, we substantially increase the subject sample size compared to
existing literature, to create a multi-centre, normative map of brain activity
which additionally considers the effects of age, sex and recording site.
Methods: Using interictal icEEG recordings from n = 513 subjects originating
from 15 centres, we constructed a normative map of non-pathological brain
activity by regressing age and sex on relative band power in five frequency
bands, whilst accounting for the site effect.
Results: Recording site significantly impacted normative icEEG maps in all
frequency bands, and age was a more influential predictor of band power than
sex. The age effect varied by frequency band, but no spatial patterns were
observed at the region-specific level. Certainty about regression coefficients
was also frequency band specific and moderately impacted by sample size.
Conclusion: The concept of a normative map is well-established in
neuroscience research and particularly relevant to the icEEG modality, which
does not allow healthy control baselines. Our key results regarding the site
and age effect guide future work utilising normative maps in icEEG.
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