Patient-derived Hormone-naive Prostate Cancer Xenograft Models Reveal Growth Factor Receptor Bound Protein 10 as an Androgen Receptor-repressed Gene Driving the Development of Castration-resistant Prostate Cancer.

Jun Hao,Xinpei Ci,Hui Xue,Rebecca Wu,Xin Dong,Stephen Yiu Chuen Choi,Haiqing He,Yu Wang,Fang Zhang,Sifeng Qu,Fan Zhang,Anne M Haegert,Peter W Gout,Amina Zoubeidi,Colin Collins,Martin E Gleave,Dong Lin,Yuzhuo Wang

European Urology（2018）

引用 19|浏览65

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摘要

Using hormone-naive patient-derived xenograft models and matched host castration-induced castration-resistant prostate cancers (CRPCs), we found and validated, for the first time, that growth factor receptor bound protein 10 (GRB10) is a CRPC driver, suggesting a novel therapeutic target for improved CRPC therapy and delaying the development of treatment resistance.

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关键词

Androgen deprivation therapy,Castration-resistant prostate cancer,Growth factor receptor bound protein 10,Patient-derived xenografts

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