The ESR1 and GPX1 gene expression level in human malignant and non-malignant breast tissues.

Magdalena B Król, Michał Galicki,Peter Grešner,Edyta Wieczorek,Ewa Jabłońska,Edyta Reszka,Zbigniew Morawiec,Wojciech Wąsowicz,Jolanta Gromadzińska

Acta biochimica Polonica（2018）

引用 12|浏览16

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摘要

Our data suggest that down-regulation of ESR1 and GPX1 was independent of clinicopathological factors. Down-regulation of ESR1 gene expression was enhanced by the development of the disease. Moreover, GPX1 and ESR1 gene expression was interdependent in the malignant breast tissue and further work is needed to determine the mechanism underlying this relationship.

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关键词

estrogen receptor,antioxidant enzymes,gene expression,breast cancer tissue

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