Relationship between soluble CD25 and gene expression in healthy individuals and patients with multiple sclerosis.

Sophie Buhelt,Rikke Lenhard Ratzer,Jeppe Romme Christensen,Lars Börnsen,Finn Sellebjerg,Helle Bach Søndergaard

Cytokine（2017）

引用 12|浏览9

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摘要

•We confirm that the IL2RA gene SNP rs2104286 affects sCD25 in HCs and MS patients.•Levels of sCD25 correlate with gene expression in PBMCs from HCs.•Fewer genes correlate with sCD25 in PBMCs from MS subtypes.•The sCD25-correlating genes in HCs are associated with innate immune cell subsets.•The sCD25-correlating genes in HCs are connected to NFKB1, TNF, BCL6 and STAT1.

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关键词

GWAS,CD25,MS,PBMC,HC,sCD25,FDR,RRMS,SPMS,PPMS,SNP,HLA,Treg cells,NK cells,DC,GM-CSF,AICD,EAE,INFγ,ANOVA,IPA

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