CDC42 regulates the Expression of Superficial Zone Molecules in part through the Actin Cytoskeleton and Myocardin-Related Transcription Factor-A
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2018.
Actin CytoskeletonCDC42 pathwayMRTF-AProteoglycan 4Superficial Zone ChondrocytesMore(1+)
Osteoarthritis (OA) is a degenerative disease that initially manifests as loss of the superficial zone (SZ) of articular cartilage. SZ chondrocytes (SZC) differ in morphology from other chondrocytes as they are elongated and oriented parallel to the tissue surface. Proteoglycan 4 (PRG4) and tenascin C (TNC) are molecules expressed by SZC,...More
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