Secretion of Hepatitis C Virus Replication Intermediates Reduces Activation of Toll Like Receptor 3 in Hepatocytes.
Gastroenterology(2018)
摘要
Using hepatocyte-based culture models for HCV, we found a portion of HCV dsRNA intermediates to be released from infected cells in EVs, which reduces activation of TLR3. This represents a novel mechanism how HCV evades host immune responses, potentially contributing to viral persistence.
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关键词
Exosomes,Escape,Virology,Rab27a
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