Optimized anion exchange column isolation of zirconium-89 ( 89 Zr) from yttrium cyclotron target: Method development and implementation on an automated fluidic platform.

•Zr sorption and desorption performance on anion exchangers are compared.•Fluidic system is used to optimize 89Zr isolation conditions from Y targets.•Fluoride complexation of 89Zr is used to enhance elution performance.•Method demonstrates >95% yield of 89Zr from Y cyclotron targets.•89Zr is separated from undesirable Fe impurity in Y foils.