Longitudinal profile of NT-proBNP levels in ischemic heart failure patients undergoing surgical ventricular reconstruction: The Biomarker Plus study.

•Natriuretic peptides are released primarily from myocytes in response to ventricular dilatation and pressure overload.•In ischemic HF patients NT-proBNP profile may be useful in predicting the outcome after surgery.•Serial levels at different time points are associated with a modulation of the risk of adverse events.•Different NT-proBNP profiles are important indicators for monitoring the evolution of the disease.