Development of cross-protective Eimeria-vectored vaccines based on apical membrane antigens

Iván Pastor-Fernández,Sungwon Kim,Karen Billington,Janene Bumstead,Virginia Marugán-Hernández,Tatiana Küster,David J.P. Ferguson,Lonneke Vervelde,Damer P. Blake,Fiona M. Tomley

International Journal for Parasitology（2018）

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摘要

•Eimeria tenella harbours four different stage-specific AMA1 paralogues.•EtAMA1, but not EtAMA2, is involved in sporozoite invasion.•EtAMA1, but not EtAMA2, induces significant protection against E. tenella challenge.•Vaccination with transgenic E. tenella [EmAMA1] parasites induces partial protection against challenge with Eimeria maxima.

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关键词

Eimeria tenella,Eimeria maxima,Apical membrane antigen,AMA1,AMA2,Vaccine delivery vector,Cross protection,Heterologous protection

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